DCA for Cancer

BCA (CHCl2) is sometimes referred to as dichloroacetic acid.

The structure of two chloroacetic acid, labeled as 2COOH, is akin to acetic acid but two of the hydrogens of the methyl groups are replaced with chlorine atoms. Different forms of dichloroacetatessuch as its esters and salts, have many potential uses. Moreover, scientists have started to study the potential of dichloroacetates as a potential medicine due to their capability of blocking pyruvate dehydrogenase kinase.

Evidence gathered from observing animal and laboratory experiments suggests that DCA could possibly retard the development of some cancers; however, there is not enough evidence yet to advise that it be used to treat cancer.

A dialect that is based on the geographical differences of the Northern and Southern Hemispheres and one that has an unpredictable nature.

This organic acid’s pKa is relatively high, at 1.35, and it produces the dichloroacetate ion when mixed with water. If breathed in, however, it is quite hazardous and can harm the mucous membranes of the respiratory tract and the pathways of the airways.

Research has discovered that Asparagopsis taxiformis has a slight concentration of dichloroacetic acid (DCA). This chemical is generated through chlorination of regular drinking water as a result of metabolism of chlorine-compatible drugs and materials. A fundamental process for the production of DCA is the reduction of trichloroacetic acid. Furthermore, it can be made through a blend of chloral hydrate, calcium carbonate, sodium cyanide, water, and hydrochloric acid. A different approach is to pair hypochlorous acid with acetylene to form DCA.

In a laboratory setting, DCA for Cancer treatment and TCA are typically utilized as substances that transport large molecules like proteins from a liquid to a solid form.

The usefulness of therapy given through the localized evaporization of chemicals can be seen through DCA and TCA (i.e. trichloroacetic acid). This practice is used in both medical treatments such as genital wart chemoablation and aesthetic procedures like chemical peels or tattoo removal. Additionally, it is possible to use these substances to precisely target and annihilate healthy cells.

A trial involving DCA conducted with 15 children diagnosed with MELAS (which is a disorder of decreased mitochondrial activity that leads to lactic acidosis) had to be stopped prematurely due to considerable neurological harm the drug caused. Studies also suggested that DCA was risk-free based on a randomized trial; however, that did not improve the condition of newborns suffering from congenital lactic acidosis. When used to fight cancer, it was found to lessen the amount of lactic acid in adult patients’ blood, but there was no improvement in their overall health and it did not extend life.

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Despite early research and lab tests indicating that DCA might assist with lactic acidosis, numerous trials involving direct comparison have proved it to be ineffective in this specific situation. Furthermore, the side effects of the drug became so severe that individuals could not keep taking it for testing purposes.

Researchers from the University of Alberta led by Evangelos Michelakis in 2007 found that consuming sodium dichloroacetate (the sodium version of dichloroacetic acid) decreased tumors in rats and eradicated cancerous cells in laboratory tests. An article in New Scientist recently caught the attention of readers due to introducing a simple and effective therapeutic approach that is considered to be relatively safe and can treat a variety of cancers.

The editorial mentioned in the study said that drug companies had no motivation to pursue approval of a cancer remedy if they could not legally defend it through the patent process. Subsequent articles in the journal discussed the potential side effects, such as nerve damage, associated with its use. In the United States, chemicals claimed to treat cancer cannot be sold without being approved by the FDA beforehand.

In 2012, the American Cancer Society reported that there was not enough evidence to demonstrate that DCA should be utilized for cancer treatments. Medical professionals pointed out that caution must be taken when utilizing DCA and it should not be employed outside of a controlled research study.

If you are looking into getting the chemical, you could run into problems. A scammer was found guilty and sentenced to 33 months in prison because they deceived cancer sufferers by telling them the white powder they had purchased was the medication DCA, in reality, it was only plain starch.

Although only a few patients with glioblastoma were included in the one study taking place with human participants, the purpose was not to test the efficacy of DCA against this type of cancer. Instead, the primary reason for the study was to determine if a particular dose of the drug could be used without causing neuropathy.

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The research included five people who were taking additional medications. The results from tests with animals and in a laboratory environment indicate that DCA could possibly be used to get rid of glioblastoma by causing the mitochondria to depolarize, leading to the destruction of the cancerous cells. Experiments conducted with neuroblastomas (which lack proper mitochondrial activity) revealed that DCA had an effect on immortal, cancerous cells.

A case report in 2016 assessed the potential of DCA to address cancers that occur in the central nervous system. Later on in 2018, a study was conducted that showed DCA to be able to make Cancer cells alter their metabolic process from glycolysis to a Warburg effect with increased levels of oxidative stress. This response wasn’t visible in healthy cells.

The termination of a few DCA clinical studies was because of neuropathy, but in 2008 an article in the British Journal of Clinical Pharmacology revealed that this problem did not occur in different DCA tests. Nonetheless, the exact way in which DCA induces neuropathy is still unknown.

Research on neurons grown in the lab has enlightened us to the neuropathic effects of DCA. Going further, it has been noted that prolonged and continuous use of DCA can stripping away the layer around nerve cells in a dose-dependent pattern. However, an analysis of the same data in 2008 showed that nerve damage takes the form of a length-dependent disorder of the axons of sensory neurons, but no demyelination happened. Kaufman et al.’s 2006 study was used to back up this claim.

Researchers have conducted studies to determine whether DCA (dichloroacetate) could be of benefit to those with long-term heart failure resulting from blocked arteries. An additional advantage of using DCA is that it increases metabolic rate by increasing levels of NADH, though when oxygen is present, NADH might be depleted. Visit source: https://www.dcaguide.org/


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